Endpoint

When investigators measure the effect of treatment on an aggregate of endpoints of varying importance, this is a composite endpoint. Inferences from composite endpoints are strongest in the rare situations in which 1) the component endpoints are of similar patient-importance, 2) the endpoints which are more important occur with at least similar frequency to those that are less important, and 3) strong biological rationale supports results that, across component endpoints, show similar relative risks with sufficiently narrow confidence intervals.